Table 3.
List of MAVS candidate interaction partners.
| MAVS FL | MAVS PR | Gene name | Protein accession | Protein name | PPI databases |
|---|---|---|---|---|---|
| Yes | ACLY | P53396 | ATP-citrate synthase | ||
| Yes | EEF2 | P13639 | Elongation factor 2 | ||
| Yes | PKM | P14618 | Pyruvate kinase PKM | ||
| Yes | TRAF2 | Q12933 | TNF receptor–associated factor 2 | Yes | |
| Yes | Yes | ADK | P55263 | Adenosine kinase | |
| Yes | Yes | AHCY | P23526 | Adenosylhomocysteinase | |
| Yes | Yes | ASNA1 | O43681 | ATPase ASNA1 | |
| Yes | Yes | ASS1 | P00966 | Argininosuccinate synthase | |
| Yes | Yes | BAG6 | P46379 | Large proline-rich protein BAG6 | Yes |
| Yes | Yes | BROX | Q5VW32 | BRO1 domain–containing protein BROX | |
| Yes | Yes | CHMP1A | Q9HD42 | Charged multivesicular body protein 1a | |
| Yes | Yes | CHMP1B | Q7LBR1 | Charged multivesicular body protein 1b | |
| Yes | Yes | CHMP2A | O43633 | Charged multivesicular body protein 2a | |
| Yes | Yes | CHMP4B | Q9H444 | Charged multivesicular body protein 4b | |
| Yes | Yes | DYNC1H1 | Q14204 | Cytoplasmic dynein 1 heavy chain 1 | |
| Yes | Yes | EPRS | P07814 | Bifunctional glutamate/proline--tRNA ligase | |
| Yes | Yes | FERMT3 | Q86UX7 | Fermitin family homolog 3 | |
| Yes | Yes | FLNA | P21333 | Filamin-A | |
| Yes | Yes | GAPDH | P04406 | Glyceraldehyde-3-phosphate dehydrogenase | |
| Yes | Yes | GET4 | Q7L5D6 | Golgi-to-ER traffic protein 4 homolog | |
| Yes | Yes | HLA-C | P10321 | HLA class I histocompatibility antigen, Cw-7 alpha chain | |
| Yes | Yes | HSPB1 | P04792 | Heat shock protein β-1 | |
| Yes | Yes | HYOU1 | Q9Y4L1 | Hypoxia up-regulated protein 1 | |
| Yes | Yes | IFIT1 | P09914 | Interferon-induced protein with tetratricopeptide repeats 1 | Yes |
| Yes | Yes | IFNB1 | P01574 | Interferon beta | Yes |
| Yes | Yes | ILK | Q13418 | Integrin-linked protein kinase | |
| Yes | Yes | IST1 | P53990 | IST1 homolog | |
| Yes | Yes | MAPRE2 | Q15555 | Microtubule-associated protein RP/EB family member 2 | |
| Yes | Yes | MAVS | Q7Z434 | Mitochondrial antiviral-signaling protein | |
| Yes | Yes | MITD1 | Q8WV92 | MIT domain–containing protein 1 | |
| Yes | Yes | PRPF19 | Q9UMS4 | Pre-mRNA–processing factor 19 | |
| Yes | Yes | RAD23B | P54727 | UV excision repair protein RAD23 homolog B | |
| Yes | Yes | RBBP7 | Q16576 | Histone-binding protein RBBP7 | |
| Yes | Yes | SAR1A | Q9NR31 | GTP-binding protein SAR1a | |
| Yes | Yes | SEPT2 | Q15019 | Septin-2 | |
| Yes | Yes | SGTA | O43765 | Small glutamine-rich tetratricopeptide repeat–containing protein alpha | |
| Yes | Yes | TLN1 | Q9Y490 | Talin-1 | |
| Yes | Yes | UBL4A | P11441 | Ubiquitin-like protein 4A | |
| Yes | Yes | UBQLN1 | Q9UMX0 | Ubiquilin-1 | |
| Yes | Yes | UBQLN4 | Q9NRR5 | Ubiquilin-4 | |
| Yes | Yes | VPS4A | Q9UN37 | Vacuolar protein sorting–associated protein 4A | |
| Yes | Yes | VTA1 | Q9NP79 | Vacuolar protein sorting–associated protein VTA1 homolog | |
| Yes | Yes | WDR1 | O75083 | WD repeat–containing protein 1 | |
| Yes | ACTL6A | O96019 | Actin-like protein 6A | ||
| Yes | CAD | P27708; P31327 | CAD protein | ||
| Yes | DPYSL2 | Q16555 | Dihydropyrimidinase-related protein 2 | ||
| Yes | PGM1 | P36871 | Phosphoglucomutase-1 | ||
| Yes | PKRKACB | P22694 | cAMP-dependent protein kinase catalytic subunit beta | ||
| Yes | PLK1 | P53350 | Serine/threonine protein kinase PLK1 | ||
| Yes | PRKDC | P78527 | DNA-dependent protein kinase catalytic subunit | ||
| Yes | PYGL | P06737 | Glycogen phosphorylase, liver form | ||
| Yes | SEPT7 | Q16181 | Septin-7 |
MAVS FL and PR Virotrap experiments were performed in triplicate, and data were compared with eDHFR control samples. The first two columns indicate whether a protein was identified as a candidate MAVS FL or PR interaction partner, and the last column indicates whether a protein is a known MAVS interaction partner as listed in the BioGRID, STRING, and/or IntAct databases.