Table 5.
Main pharmacokinetic parameters (mean ± SD) following IP administration of DOX, oral administration of SOR and co-administration to rats (n = 5).
| GROUP I DOX (5 mg/kg) | GROUP III DOX Mix | GROUP II SOR (40 mg/kg) | GROUP III SOR Mix | |
|---|---|---|---|---|
| Cmax (ng/mL) | 196.1 ± 166.2 | 846.9 ± 60.4 | 20.4 ± 3.6 | 29.6 ± 3.6 |
| Tmax (h)* | 1 | 2 | 4 | 2 |
| AUC0-t (ng.h/mL) | 1856.6 ± 459.8 | 3617.7 ± 322.9 | 547.1 ± 125.7 | 398.6 ± 118.7 |
| AUC0-∞ (ng.h/mL) | 2781.9 ± 366.8 | 6271.1 ± 1975.5 | 591.6 ± 141.3 | 557.9 ± 195.7 |
| t½ (h) | 51.1 ± 18.9 | 68.2 ± 37.6 | 18.3 ± 3.1 | 42.8 ± 24.2 |
| CL/F (L/h/kg) | 1.8 ± 0.2 | 0.8 ± 0.2 | 70.7 ± 16.4 | 77.7 ± 23.7 |
*Tmax (h) is presented as a median.