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. 2023 Apr 16;83(12):1953–1967. doi: 10.1158/0008-5472.CAN-22-3848

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©2023 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 2. Mutation of Keap1 or Nrf2 is not sufficient to initiate lung tumorigenesis. A, Overall survival of Keap1/Nrf2 mutant mice. Keap1/Nrf2+/+ (n = 17), Keap1R554Q/+ (n = 8); Keap1R554Q/R554Q (n = 11); Nrf2D29H/+ (n = 15). ns, not significant [log-rank (Mantel–Cox) test]. B, Lung tumor-free survival of Keap1/Nrf2 mutant mice. Keap1/Nrf2+/+ (n = 11); Keap1R554Q/+ (n = 4); Keap1R554Q/R554Q (n = 8); Nrf2D29H/+ (n = 11). C, Representative hematoxylin and eosin staining of mouse lung depicting normal bronchiolar and alveolar cells. Scale bars, 100 μm (top) and 20 μm (bottom). — Mutation of Keap1 or Nrf2 is not sufficient to initiate lung tumorigenesis. A, Overall survival of Keap1/Nrf2 mutant mice. Keap1/Nrf2^+/+ (n = 17), Keap1^R554Q/+ (n = 8); Keap1^R554Q/R554Q (n = 11); Nrf2^D29H/+ (n = 15). ns, not significant [log-rank (Mantel–Cox) test]. B, Lung tumor-free survival of Keap1/Nrf2 mutant mice. Keap1/Nrf2^+/+ (n = 11); Keap1^R554Q/+ (n = 4); Keap1^R554Q/R554Q (n = 8); Nrf2^D29H/+ (n = 11). C, Representative hematoxylin and eosin staining of mouse lung depicting normal bronchiolar and alveolar cells. Scale bars, 100 μm (top) and 20 μm (bottom).