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. 2023 Apr 16;83(12):1953–1967. doi: 10.1158/0008-5472.CAN-22-3848

Figure 6.

Figure 6. Nrf2 expression and activity are reduced in higher-grade tumors. A, Representative Nrf2 and Nqo1 IHC staining in grade 1 and 4 tumors from KrasG12D/+; p53fl/fl mice with Keap1 or Nrf2 mutation. Scale bars, 20 μm. B and C, Heatmaps depicting the H-scores per grade from IHC staining for Nrf2 (nuclear; B) and the Nrf2 target Nqo1 (whole cell; C). N = 3 mice per genotype, >20,000 tumor cells per mouse. Only one grade 5 tumor was found in the Keap1R554Q/R554Q cohort, and therefore was excluded from these analyses.

Nrf2 expression and activity are reduced in higher-grade tumors. A, Representative Nrf2 and Nqo1 IHC staining in grade 1 and 4 tumors from KrasG12D/+; p53fl/fl mice with Keap1 or Nrf2 mutation. Scale bars, 20 μm. B and C, Heatmaps depicting the H-scores per grade from IHC staining for Nrf2 (nuclear; B) and the Nrf2 target Nqo1 (whole cell; C). N = 3 mice per genotype, >20,000 tumor cells per mouse. Only one grade 5 tumor was found in the Keap1R554Q/R554Q cohort, and therefore was excluded from these analyses.