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. 2023 May 22;15(5):2544–2558. doi: 10.21037/jtd-22-1731

Table 3. Correlation between metabolites and lung function parameters in mice.

Lung function parameters Values Arginine Leucine Phenylalanine α-Linolenic acid Palmitic acid Linoleic acid Adipoylcarnitine Malonylcarnitine
FEV25/FVC r −0.582* −0.284 −0.476 0.775** 0.648* 0.767** −0.378 −0.566
P 0.047 0.371 0.118 0.003 0.023 0.004 0.225 0.055
FEV50/FVC r −0.576 −0.274 −0.431 0.693* 0.582* 0.734** −0.404 −0.561
P 0.050 0.389 0.161 0.012 0.047 0.007 0.193 0.058
FRC r 0.375 0.213 0.646* −0.375 −0.227 −0.172 −0.168 0.399
P 0.230 0.506 0.023 0.230 0.478 0.592 0.601 0.198
IC r 0.838** 0.575 0.714** −0.788** −0.630* −0.832** 0.545 0.765*
P 0.001 0.051 0.009 0.002 0.028 0.001 0.067 0.004
TLC r 0.796** 0.529 0.807** −0.758** −0.577* −0.712** 0.356 0.749**
P 0.002 0.077 0.002 0.004 0.049 0.009 0.256 0.005
Cchord r 0.799** 0.489 0.590* −0.780** −0.681* −0.826** 0.555 0.722**
P 0.002 0.106 0.043 0.003 0.015 0.001 0.061 0.008

*, P<0.05; **, P<0.01. FEV25/FVC and FEV50/FVC, percentage of forced expiratory volume in first 25 and 50 ms of fast expiration of forced vital capacity; FRC, functional residual capacity; IC, individual and mean values of inspiratory capacity; TLC, total lung capacity; Cchord, chord compliance.