Table 3. Correlation between metabolites and lung function parameters in mice.
Lung function parameters | Values | Arginine | Leucine | Phenylalanine | α-Linolenic acid | Palmitic acid | Linoleic acid | Adipoylcarnitine | Malonylcarnitine |
---|---|---|---|---|---|---|---|---|---|
FEV25/FVC | r | −0.582* | −0.284 | −0.476 | 0.775** | 0.648* | 0.767** | −0.378 | −0.566 |
P | 0.047 | 0.371 | 0.118 | 0.003 | 0.023 | 0.004 | 0.225 | 0.055 | |
FEV50/FVC | r | −0.576 | −0.274 | −0.431 | 0.693* | 0.582* | 0.734** | −0.404 | −0.561 |
P | 0.050 | 0.389 | 0.161 | 0.012 | 0.047 | 0.007 | 0.193 | 0.058 | |
FRC | r | 0.375 | 0.213 | 0.646* | −0.375 | −0.227 | −0.172 | −0.168 | 0.399 |
P | 0.230 | 0.506 | 0.023 | 0.230 | 0.478 | 0.592 | 0.601 | 0.198 | |
IC | r | 0.838** | 0.575 | 0.714** | −0.788** | −0.630* | −0.832** | 0.545 | 0.765* |
P | 0.001 | 0.051 | 0.009 | 0.002 | 0.028 | 0.001 | 0.067 | 0.004 | |
TLC | r | 0.796** | 0.529 | 0.807** | −0.758** | −0.577* | −0.712** | 0.356 | 0.749** |
P | 0.002 | 0.077 | 0.002 | 0.004 | 0.049 | 0.009 | 0.256 | 0.005 | |
Cchord | r | 0.799** | 0.489 | 0.590* | −0.780** | −0.681* | −0.826** | 0.555 | 0.722** |
P | 0.002 | 0.106 | 0.043 | 0.003 | 0.015 | 0.001 | 0.061 | 0.008 |
*, P<0.05; **, P<0.01. FEV25/FVC and FEV50/FVC, percentage of forced expiratory volume in first 25 and 50 ms of fast expiration of forced vital capacity; FRC, functional residual capacity; IC, individual and mean values of inspiratory capacity; TLC, total lung capacity; Cchord, chord compliance.