Table 2. Diagnostic performance of the pleural fluid 10× ADA/LDH ratio and the ADA level for TBPE.
| Parameter | ADA total | 10× ADA/LDH | |||
|---|---|---|---|---|---|
| Total | ADA >10 U/L | ADA >20 U/L | ADA >30 U/L | ||
| Cut-off value | >40 U/L | >0.56 | >0.45 | >0.44 | >0.47 |
| Sensitivity (95% CI) | 0.47 (0.38–0.56) | 0.76 (0.68–0.82) | 0.91 (0.83–0.94) | 0.95 (0.88–0.98) | 0.95 (0.87–0.98) |
| Specificity (95% CI) | 0.82 (0.77–0.87) | 0.87 (0.82–0.91) | 0.86 (0.78–0.92) | 0.94 (0.84–0.98) | 0.96 (0.86–0.99) |
| PPV (95% CI) | 0.61 (0.51–0.70) | 0.78 (0.70–0.84) | 0.86 (0.80–0.93) | 0.96 (0.89–0.99) | 0.97 (0.90–1.00) |
| NPV (95% CI) | 0.73 (0.67–0.78) | 0.86 (0.80–0.90) | 0.90 (0.82–0.94) | 0.92 (0.82–0.97) | 0.93 (0.81–0.98) |
| PLR (95% CI) | 2.65 (1.90–3.71) | 5.81 (4.13–8.17) | 6.64 (4.13–10.66) | 15.44 (5.97–39.93) | 24.7 (6.34–96.23) |
| NLR (95% CI) | 0.64 (0.55–0.76) | 0.28 (0.21–0.37) | 0.11 (0.06–0.19) | 0.05 (0.02–0.13) | 0.05 (0.02–0.14) |
| Youden index | 0.29 | 0.63 | 0.77 | 0.89 | 0.91 |
ADA, adenosine deaminase; LDH, lactate dehydrogenase; TBPE, tuberculous pleural effusion; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value; PLR, positive likelihood ratio; NLR, negative likelihood ratio.