Table 2. Tissue types of the tiles used for different prediction targets.
Prediction categories | Prediction targets | Tissue types of tiles sampled |
---|---|---|
Clinical pathological features | T1 | Tumor |
T2–3 | Tumor | |
N0 | Tumor | |
N1–3 | Tumor | |
Grade I | Tumor | |
Grade II | Tumor | |
Grade III | Tumor | |
Low Ki67 | Tumor | |
High Ki67 | Tumor | |
Somatic mutations | PIK3CA | Tumor |
TP53 | Tumor | |
GATA3 | Tumor | |
MAP3K1 | Tumor | |
KMT2C | Tumor | |
AKT1 | Tumor | |
PTEN | Tumor | |
FAT3 | Tumor | |
SF3B1 | Tumor | |
Gene set enrichment analysis scores | Angiogenesis | Tumor |
DNA repair | Tumor | |
Estrogen response early | Tumor | |
G2-M checkpoint | Tumor | |
IFN-γ response | Tumor | |
PI3K/AKT/mTOR signaling | Tumor | |
Immunotherapy biomarkers | iTILs | Tumor |
sTILs | Stroma and immune infiltrates | |
CD8A mRNA | Stroma and immune infiltrates | |
PDCD1 mRNA | Stroma and immune infiltrates | |
CD274 mRNA | Tumor, stroma and immune infiltrates | |
Prognosis | OS | All five tissue types |
DFS | All five tissue types |
iTILs, intratumoral tumor-infiltrating lymphocytes; sTILs, stromal tumor-infiltrating lymphocytes; OS, overall survival; DFS, disease-free survival.