TABLE 4.

Two drug interactions of resveratrol combined with either azithromycin or imidocarb dipropionate on the in vivo growth of B. microti on day 10 exhibited peak parasitemia.

Drug combination	FICD1	FICD2	ΣFIC	Degree of interaction a
Azithromycin
	1	1.12	2.12	antagonistic
Imidocarb dipropionate
	0.13	0.47	0.61	additive

^a The degree of drug interaction was determined based on the following fractional inhibitory concentration (FIC) index: >0.5–1 (additive), >1 to <2 (indifferent), and ≥2 (antagonistic). FICD1 is the fractional inhibitory concentration of resveratrol. Meanwhile, FICD2 is the fractional inhibitory concentration of either azithromycin or imidocarb dipropionate.