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. 2023 May 30;15:1198159. doi: 10.3389/fnsyn.2023.1198159

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Copyright © 2023 Ueberbach, Simacek, Tegeder, Kirischuk and Mittmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The reduced frequency of miniature excitatory postsynaptic currents (mEPSCs) is mediated by activity from presynaptic GABA_B receptors (GABA_BRs) at glutamatergic synapses. (A) Representative mEPSCs of P14 and P21 mice under control condition (left), in presence of Baclofen (10 μM, middle) and in CGP55845 (1 μM, right trace). (B1,B2) Summary diagrams of the relative mean frequency of mEPSCs in presence of the GABA_BR agonist Baclofen normalized to the recordings made in control artificial cerebrospinal fluid (ACSF). (B2) Note the significantly smaller reduction in the frequency in wild-type (WT)-animals at P21. (C1,C2) The GABA_BR- antagonist CGP55845 restored the mEPSC frequency back to control levels in WT mice at P14 and at P21. Note, CGP55845 strongly increased the mEPSC frequency in KI-mice above the level of the control data.