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. 2023 May 30;15:1198159. doi: 10.3389/fnsyn.2023.1198159

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Copyright © 2023 Ueberbach, Simacek, Tegeder, Kirischuk and Mittmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spontaneous cortical network activity of acute coronal brain slices is affected by Baclofen and CGP55845. (A) Representative voltage traces from multi-electrode array (MEA) recordings under control conditions in P14 and P21 mice (left column traces). (B1,B2) The mean spike frequency is impaired in KI mice at P14 in normal artificial cerebrospinal fluid (ACSF). (C) Representative voltage traces in presence of Baclofen (10 μM, middle column). (D1,D2) Baclofen further reduced the mean spike frequencies. Note, the impairment is weaker in KI mice at P21 compared to wild-type (WT) littermates. (E) Representative voltage traces in presence of CGP55845 (1 μM). (F1,F2) CGP55845 rescued the level of spontaneous activity back to control levels in P21 mice. Note the spike frequencies are no longer significantly different between KI and WT mice at P14.