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. 2023 May 30;15:1198159. doi: 10.3389/fnsyn.2023.1198159

FIGURE 7.

FIGURE 7

Blockade of the astrocytic transporter GABA transporter 3 (GAT-3) increases both, frequency of miniature excitatory postsynaptic currents (mEPSCs) and spontaneous activity in KI mice at P14. (A) Representative traces of mEPSCs in controls (left) and after incubation of SNAP5114 (50 μM, right). (B) Representative voltage traces of spontaneous activity by multi-electrode array (MEA) recordings under control conditions (left) and after incubation with SNAP5114 (right). (C1,C2) Summary diagram of the mean frequency of mEPSCs in KI and WI mice in controls and in the presence of SNAP5114. Note that the mEPSC frequency recovers to a level similar to wild-type (WT)-mice in presence of the GABA transporter 3 (GAT-3)-blocker in KI animals (C2). (D1,D2) Summary diagram of the mean spontaneous activity in the cortical slice in KI and WI mice in controls and in presence of SNAP5114. Also, the spontaneous activity increases to the level of WT-mice in SNAP5114 (D2).