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. 2023 Jun 2;8(23):20196–20233. doi: 10.1021/acsomega.3c01558

Table 1. Some Pyridopyrimidine Analogues^a.

structure	comp	R	R¹	R²	R³	IC₅₀(μM)
VI	35	2′,6′-diCl, 3′-OH Bn	Me	H	3-phenoxypropanoic acid	0.04
VI	36	2′-Cl Bn	Me	Me	N,N-diethyl-2-phenoxyethan-1-amine	0.55

structure	comp	R	R¹	R²	R³	K_i (nM)
VII	37	2′,6′-diCl Bn	Me	–	1-phenylpiperazine	0.3
VII	38	2′,6′-diCl Bn	Me	–	N-methyl-1,2,3,4-tetrahydroisoquinoline	0.2
VIII	39	2′,6′-diCl Bn	CH₂OH	–	2,4,4-trimethyl-1,2,3,4-tetrahydroisoquinoline	0.3
VIII	40	2′,6′-diCl Bn	Me	–	1-methyl-4-phenylpiperazine	0.5

^a

Bn stands for benzene.