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. 2023 Jun 2;8(23):20196–20233. doi: 10.1021/acsomega.3c01558

Table 6. Toxicity profile of clinical candidatesa.

candidate toxicities grade
AZD1775 myelosuppression ≥3
  GI toxicities 1—3
  fatigue 3
ZN-c3 GI toxicities all
  neutropenia ≥3
IMP7068 increased ALT 1 or 2
  increased AST 1 or 2
  diarrhea 1 or 2
Debio-0123 NA NA
SY-4835 NA NA
a

NA = not available.