Table 6. Toxicity profile of clinical candidatesa.
| candidate | toxicities | grade |
|---|---|---|
| AZD1775 | myelosuppression | ≥3 |
| GI toxicities | 1—3 | |
| fatigue | 3 | |
| ZN-c3 | GI toxicities | all |
| neutropenia | ≥3 | |
| IMP7068 | increased ALT | 1 or 2 |
| increased AST | 1 or 2 | |
| diarrhea | 1 or 2 | |
| Debio-0123 | NA | NA |
| SY-4835 | NA | NA |
NA = not available.