Table 6. Toxicity profile of clinical candidatesa.
candidate | toxicities | grade |
---|---|---|
AZD1775 | myelosuppression | ≥3 |
GI toxicities | 1—3 | |
fatigue | 3 | |
ZN-c3 | GI toxicities | all |
neutropenia | ≥3 | |
IMP7068 | increased ALT | 1 or 2 |
increased AST | 1 or 2 | |
diarrhea | 1 or 2 | |
Debio-0123 | NA | NA |
SY-4835 | NA | NA |
NA = not available.