Single-Layered Materials |
PCL |
lab scale |
abdominal |
yes, comparable to Interceed (small animal model) |
no |
yes |
hydrophobic |
Interceed |
(16) |
|
large scale |
abdominal |
no (large animal model) |
no |
yes |
hydrophobic |
no |
(10) |
|
lab scale |
abdominal |
yes (small animal model) |
antibiotic Biteral |
yes |
n.a. (PCL known to be hydrophobic) |
no |
(19) |
|
lab scale |
tendon |
yes (small animal model) |
chitosan |
yes |
hydrophilic (due to chitosan) |
Seprafilm |
(23) |
|
lab scale |
abdominal |
yes |
curcumin |
yes |
hydrophobic |
no |
(24) |
|
lab scale |
tendon |
yes (small animal model) |
grafting of a copolymer synthesized by DMA and MPC |
n.a. |
hydrophobic |
no |
(27) |
PLLA |
lab scale |
abdominal |
no, lower effect than Interceed (small animal model) |
no |
yes |
hydrophobic |
Interceed |
(16) |
|
lab scale |
tendon |
yes (small animal model) |
mitomycin C |
yes |
hydrophobic |
no |
(21) |
PLGA |
lab scale |
abdominal |
yes, higher than Interceed (small animal model) |
no |
yes |
hydrophobic |
Interceed |
(16) |
|
lab scale |
abdominal |
yes (small animal model) |
antibiotics (cefoxitin sodium) |
yes |
n.a. |
no |
(18) |
|
lab scale |
epidural |
yes (small animal model) |
two types of ibuprofen |
yes |
hydrophobic |
no |
(20) |
|
lab scale |
abdominal |
yes,
close values to Interceed (small animal model) |
polyphenol epigallocatechin-3-O-gallate |
yes |
n.a. |
Interceed |
(22) |
|
lab scale |
abdominal |
yes (small animal model) |
PEG |
yes |
hydrophilic |
no |
(25) |
|
lab scale |
epidural |
yes (small animal model) |
PVP + phosphatidylcholine |
yes |
hydrophilic |
Interceed |
(28) |
PES |
lab scale |
abdominal |
no (small animal model) |
no |
no |
hydrophobic |
Interceed |
(16) |
PU |
lab scale |
abdominal |
yes (small animal model) |
no |
yes |
n.a. |
PMS Stripsck |
(17) |
PLCL |
large scale |
abdominal |
no (large animal model) |
no |
yes |
hydrophobic |
none |
(10) |
PVDF |
lab scale |
antifibrotic (glaucoma treatment) |
yes (in vitro fibroblasts) |
PEO |
no |
hydrophobic |
none |
(26) |
Multilayered Materials |
PCL/HA |
lab scale |
abdominal |
yes (small animal model) |
no |
yes |
n.a. (HA known
to be hydrophilic;
PCL known to be hydrophobic) |
none |
(29) |
PLLA (three layers) |
lab scale |
tendon |
yes (in vitro model) |
collagen, chitosan, alginate |
yes |
n.a. |
none |
(30) |
PEG/PCL/HA |
lab scale |
tendon |
yes (small animal model) |
AgNPs + ibuprofen |
yes |
hydrophobic PEG/PCL sheath,
hydrophilic HA |
none |
(31) |
PVA/PCL |
large scale |
abdominal |
no (large animal model) |
no |
yes |
hydrophilic side (PVA)/hydrophobic
side (PCL) |
none |
(11, 32) |
PCL/HMDSO |
large
scale |
abdominal |
yes (ex vivo model) |
PCL droplets |
yes |
hydrophobic |
none |
(33) |