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. 2023 May 27;8(23):20152–20162. doi: 10.1021/acsomega.3c00341

Table 2. Overview of Developed Nanofibrous Materials and Their Measured Properties.

polymer electrospinning type of adhesion antiadhesive effect combination of nanofibers with other structures/substances degradability wettability comparison with commercial materials ref
Single-Layered Materials
PCL lab scale abdominal yes, comparable to Interceed (small animal model) no yes hydrophobic Interceed (16)
  large scale abdominal no (large animal model) no yes hydrophobic no (10)
  lab scale abdominal yes (small animal model) antibiotic Biteral yes n.a. (PCL known to be hydrophobic) no (19)
  lab scale tendon yes (small animal model) chitosan yes hydrophilic (due to chitosan) Seprafilm (23)
  lab scale abdominal yes curcumin yes hydrophobic no (24)
  lab scale tendon yes (small animal model) grafting of a copolymer synthesized by DMA and MPC n.a. hydrophobic no (27)
PLLA lab scale abdominal no, lower effect than Interceed (small animal model) no yes hydrophobic Interceed (16)
  lab scale tendon yes (small animal model) mitomycin C yes hydrophobic no (21)
PLGA lab scale abdominal yes, higher than Interceed (small animal model) no yes hydrophobic Interceed (16)
  lab scale abdominal yes (small animal model) antibiotics (cefoxitin sodium) yes n.a. no (18)
  lab scale epidural yes (small animal model) two types of ibuprofen yes hydrophobic no (20)
  lab scale abdominal yes, close values to Interceed (small animal model) polyphenol epigallocatechin-3-O-gallate yes n.a. Interceed (22)
  lab scale abdominal yes (small animal model) PEG yes hydrophilic no (25)
  lab scale epidural yes (small animal model) PVP + phosphatidylcholine yes hydrophilic Interceed (28)
PES lab scale abdominal no (small animal model) no no hydrophobic Interceed (16)
PU lab scale abdominal yes (small animal model) no yes n.a. PMS Stripsck (17)
PLCL large scale abdominal no (large animal model) no yes hydrophobic none (10)
PVDF lab scale antifibrotic (glaucoma treatment) yes (in vitro fibroblasts) PEO no hydrophobic none (26)
Multilayered Materials
PCL/HA lab scale abdominal yes (small animal model) no yes n.a. (HA known to be hydrophilic; PCL known to be hydrophobic) none (29)
PLLA (three layers) lab scale tendon yes (in vitro model) collagen, chitosan, alginate yes n.a. none (30)
PEG/PCL/HA lab scale tendon yes (small animal model) AgNPs + ibuprofen yes hydrophobic PEG/PCL sheath, hydrophilic HA none (31)
PVA/PCL large scale abdominal no (large animal model) no yes hydrophilic side (PVA)/hydrophobic side (PCL) none (11, 32)
PCL/HMDSO large scale abdominal yes (ex vivo model) PCL droplets yes hydrophobic none (33)