Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Role of nestin in cytoskeletal signaling. Contractile stimulation promotes the association of nestin with Plk1, which facilitates nestin phosphorylation at Thr-315, and renders Plk1 in active state. This nestin/Plk1 interaction forms a positive activation loop. Activated Plk1 catalyzes vimentin phosphorylation at Ser-56, which subsequently promotes the recruitment of cortactin and Pfn-1 to the membrane, actin polymerization, and smooth muscle contraction
