Table 2.
Primary and secondary outcomes in the HCQ and CS groups
| HCQ group(n = 39) | CS group (n = 39) | P value | |
|---|---|---|---|
| Primary outcomes | |||
| Proteinuria at 12 months (g/d) | 0.85 [0.50, 1.41] | 0.54 [0.19, 0.89] | 0.099 |
| Change in proteinuria at 12 months | -47.8% [-66.9%, -33.1%] | -73.5% [-89.5%, -57.0%] | 0.005 |
| Proteinuria at 24 months (g/d) | 0.97 [0.51, 1.37] | 0.53 [0.25, 1.81] | 0.707 |
| Change in proteinuria at 24 months | -50.5% [-80.6%, -3.4%] | -63.7% [-78.5%, -24.2%] | 0.385 |
| Secondary outcomes | |||
| eGFR at 12 months (mL/min/1.73 m2) | 67.54 ± 27.00 | 67.80 ± 23.69 | 0.967 |
| Change in eGFR at 12 months | -4.4% [-15.2%, -6.3%] | -2.1% [-16.0%, 8.4%] | 0.745 |
| eGFR at 24 months (mL/min/1.73 m2) | 66.10 ± 28.00 | 67.04 ± 23.80 | 0.877 |
| Change in eGFR at 24 months | -7.9% [-16.1%, 5.8%] | -6.6% [-14.9%, 5.3%] | 0.758 |
| Slope of eGFR (mL/min/1.73 m2/year) | -1.78 ± 8.23 | -1.10 ± 6.55 | 0.693 |
| eGFR decrease ≥ 50% (mL/min/1.73 m2) | 1 (3%) | 2 (5%) | 0.556 |