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. 2023 Jun 15;21:387. doi: 10.1186/s12967-023-04251-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — In vitro characterization of latozinemab. A Binding curve of sortilin-expressing HEK293T cells by latozinemab. n = 4 technical replicates for latozinemab, n = 5 technical replicates for isotype control. B Percentage of dose-dependent blocking of human PGRN binding to sortilin by latozinemab. n = 3 technical replicates for latozinemab, n = 2 technical replicates for isotype control. C Dose-dependent decrease in surface sortilin expression on U251 cells. n = 3 technical replicates for latozinemab, n = 2 technical replicates for isotype control. D Extracellular PGRN is increased relative to baseline (dashed line) in the presence of latozinemab. n = 3 technical replicates for latozinemab, n = 2 technical replicates for isotype control. All data represent the mean ± SD. 2–5 technical replicates shown for each experiment, each experiment was repeated N > 3, representative data are shown. PE, phycoerythrin; PGRN, progranulin