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cfDNA accuracy for prenatal detection of sex chromosome aneuploidy
| SCA | Pooled estimated sensitivity | 95% CI lower | 95% CI upper | Pooled estimated specificity | 95% CI lower | 95% CI upper |
|---|---|---|---|---|---|---|
| 45,X | 98.754% | 94.640% | 100% | 99.413% | 98.723% | 99.870% |
| 47,XXY | 100% | 99.559% | 100% | 99.994% | 99.935% | 100% |
| 47,XXX | 100% | 96.901% | 100% | 99.887% | 99.709% | 99.991% |
| 47,XYY | 100% | 91.284% | 100% | 100% | 99.979% | 100% |
Abbreviations: SCA, sex chromosome aneuploidy, 95% CI, 95% confidence interval; 100%, 100.000%.
