Table 3.

Association Between OSA–Hypopnea Index and Incident Hospitalization With Respiratory Infection: The ARIC Study, 1996-1998 Through 2018 (N = 1,563)

	OSA Category				P for Trend
	Normal	Mild	Moderate	Severe
	< 5 Events/h	5-14 Events/h	15-29 Events/h	≥ 30 Events/h
No.	803	467	199	94	…
Incident hospitalization with respiratory infection, No.	152	103	49	26	…
Person-y at risk	14,290	7,992	3,389	1,497	…
Crude respiratory infection incidence rate, per 1,000 person-y	10.6	12.9	14.5	17.4	…
Model 1 hazard ratio (95% CI)	1 (reference)	1.03 (0.80-1.33)	1.15 (0.83-1.60)	1.40 (0.92-2.13)	.13
Model 2 hazard ratio (95% CI)	1 (reference)	1.10 (0.85-1.43)	1.19 (0.85-1.66)	1.47 (0.96-2.25)	.07
Model 3 hazard ratio (95% CI)	1 (reference)	1.08 (0.83-1.40)	1.13 (0.80-1.59)	1.34 (0.85-2.11)	.21
Model 4 hazard ratio (95% CI)	1 (reference)	1.07 (0.82-1.39)	1.11 (0.78-1.56)	1.33 (0.85-2.10)	.25
Model 5 hazard ratio (95% CI)	1 (reference)	1.07 (0.82-1.40)	1.14 (0.80-1.61)	1.26 (0.80-1.99)	.27
Model 6 hazard ratio (95% CI)	1 (reference)	1.07 (0.82-1.40)	1.15 (0.81-1.62)	1.26 (0.80-1.97)	.27

ARIC = Atherosclerosis Risk in Communities.

Model 1: Cox regression adjusted for age, sex, and center.

Model 2: Model 1 + adjustment for education, sports index, drinking status, and smoking status.

Model 3: Model 2 + adjustment for BMI.

Model 4: Model 3 + adjustment for prevalent asthma and prevalent COPD.

Model 5: Model 4 + adjustment for estimated glomerular filtration rate (eGFR), diabetes, and prevalent cardiovascular disease.

Model 6: Model 5 + adjustment for log(C-reactive protein).