Table 4.

Association Between OSA–Hypopnea Index and Incident Hospitalized Infection: The ARIC Study, 1996-1998 Through 2018 (N = 1,475)

	OSA Category				P for Trend
	Normal	Mild	Moderate	Severe
	< 5 Events/h	5-14 Events/h	15-29 Events/h	≥ 30 Events/h
No.	750	447	189	89	…
Any incident hospitalization with infection, n	274	191	78	46	…
Person-y at risk	12,419	7,073	3,012	1,280	…
Crude infection incidence rate, per 1,000 person-y	22.1	27.0	25.9	35.9	…
Model 1 hazard ratio, 95% CI	1 (reference)	1.08 (0.89-1.31)	1.05 (0.81-1.36)	1.45 (1.05-1.99)	.07
Model 2 hazard ratio, 95% CI	1 (reference)	1.13 (0.93-1.37)	1.08 (0.83-1.40)	1.48 (1.07-2.04)	.04
Model 3 hazard ratio, 95% CI	1 (reference)	1.06 (0.87-1.29)	0.95 (0.72-1.24)	1.20 (0.85-1.69)	.58
Model 4 hazard ratio, 95% CI	1 (reference)	1.05 (0.86-1.28)	0.94 (0.72-1.23)	1.20 (0.85-1.69)	.61
Model 5 hazard ratio, 95% CI	1 (reference)	1.05 (0.86-1.28)	0.95 (0.72-1.24)	1.13 (0.80-1.59)	.76
Model 6 hazard ratio, 95% CI	1 (reference)	1.04 (0.86-1.27)	0.95 (0.73-1.25)	1.12 (0.80-1.58)	.77

ARIC = Atherosclerosis Risk in Communities.

Model 1: Cox regression adjusted for age, sex, and center.

Model 2: Model 1 + adjustment for education, sports index, drinking status, and smoking status.

Model 3: Model 2 + adjustment for BMI.

Model 4: Model 3 + adjustment for prevalent asthma and prevalent COPD.

Model 5: Model 4 + adjustment for estimated glomerular filtration rate (eGFR), diabetes, and prevalent cardiovascular disease.

Model 6: Model 5 + adjustment for log(C-reactive protein).