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. 2023 May 24;169(5):001333. doi: 10.1099/mic.0.001333

Fig. 4.

Fig. 4.

Schematic representation describing an approach to discover new efflux pump inhibitors (EPIs) from the natural products library. Screening of the natural products library could help identify novel EPIs or a group of related chemical moieties that act synergistically as a potent antibacterial agent. Screening for EPIs could be performed against recombinant strains expressing multiple efflux pumps to select a broad-spectrum EPI or collection of EPIs that can target different efflux pumps.