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(Left) Illustration of the complex of R23 and neomycin B. Base A13 flips out of the loop and appears to form a latch across the groove where the aminoglycoside sits. This structural model is very similar to that of a complex with an RNA analog of R23 (21). (Right) Summary of key electrostatic contacts formed between the proximal phosphate groups and protonated amines. The other amines are shown explicitly as not-protonated for reason of clarity only.
