TABLE 2.
FICI values for 5 antifungal combinations against 11 C. auris isolatesa
| Isolate | AFG + 5FC | AFG+mGX | AMB + 5FC | VRC + 5FC | MGX + 5FC |
|---|---|---|---|---|---|
| Median (range) | Median (range) | Median (range) | Median (range) | Median (range) | |
| B19460 | 0.49 (0.48 to 0.50) | 0.50 (0.50 to 0.52) | 1.01 (1.00 to 1.01) | 4.48 (1.01 to 8.00) | 1.01 (1.00 to 1.01) |
| B19618 | 0.56 (0.49 to 1.01) | 0.52 (0.51 to 1.00) | 1.00 (0.52 to 1.02) | 4.50 (1.02 to 5.00) | 1.00 (1.00 to 1.02) |
| B17040 | 0.56 (0.15 to 0.56) | 0.51 (0.33 to 0.55) | 1.00 (1.00 to 1.01) | 1.01 (1.00 to 1.01) | 1.01 (0.76 to 1.02) |
| B17041 | 0.74 (0.69 to 0.98) | 0.65 (0.37 to 0.77) | 1.00 (0.75 to 1.00) | 1.00 (0.56 to 1.02) | 1.00 (0.63 to 1.01) |
| B18560 | 0.60 (0.30 to 0.61) | 0.28 (0.19 to 0.75) | 1.01 (1.01) | 1.00 (1.00 to 4.48) | 0.56 (0.53 to 1.00) |
| B18843 | 0.98 (0.49 to 1.00) | 0.63 (0.53 to 0.75) | 1.00 (0.63 to 1.01) | 4.50 (1.01 to 4.50) | 1.00 (0.63 to 4.41) |
| B12694 | 0.36 (0.24 to 0.37) | 0.52 (0.20 to 0.62) | 0.63 (0.53 to 1.00) | 1.01 (1.01) | 0.54 (0.50 to 1.05) |
| B12663 | 0.74 (0.38 to 1.00) | 0.33 (0.33 to 1.01) | 0.75 (0.51 to 1.01) | 1.00 (1.00 to 1.01) | 1.01 (0.51 to 1.05) |
| B12664 | 0.75 (0.62 to 0.98) | 0.39 (0.29 to 0.51) | 0.75 (0.62 to 0.75) | 1.01 (0.63 to 1.01) | 0.58 (0.57 to 1.01) |
| B20931 | 0.53 (0.18 to 0.60) | 0.49 (0.30 to 0.56) | 1.00 (0.53 to 1.00) | 1.01 (0.63 to 1.01) | 1.01 (0.56 to 1.01) |
| B21040 | 1.02 (0.56 to 1.03) | 0.75 (0.56 to 1.00) | 0.75 (0.63 to 1.00) | 1.01 (1.01) | 1.00 (0.53 to 1.00) |
a
Synergy, dark gray; partial synergy, medium gray; indifference/additivity, white; antagonism, light gray. Underlined values indicate resistance to either AFG or VRC. 5FC, 5-flucytosine; AFG, anidulafungin; AMB, amphotericin B; MGX, manogepix; VRC, voriconazole.