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. 2023 Jun 13;15(1):2215887. doi: 10.1080/19420862.2023.2215887

Figure 6.

The amino acids of the charge cluster in the lower core region of VL and VH before (A) and after (B) application of T101R.

Residues surrounding the buried Arg77-Asp100 salt bridge forming the charge cluster in the lower core as well as Thr101 and Thr146 in the repacked Rosetta structure (a), based on crystal structure of αTAA1, and the resulting Rosetta structure after T101R has been applied (b).