FIG 4.

Transcriptomic analysis of OmpR-mediated gene expression. Differential gene expression between wild-type K. pneumoniae and its ΔompR mutant was determined by RNA-sequencing. (A) Volcano plot analysis of differentially expressed genes. A total of 273 differentially expressed genes (DEGs), including 136 upregulated and 137 downregulated genes in ΔompR, are highlighted. Representative genes are depicted in Table 2 (name or ID). The red and green dots denote significantly upregulated and downregulated genes, respectively, and the gray dots represent not differentially expressed genes. (B) The top 20 GO terms were identified by Gene Ontology analysis. (C) Metabolic pathways associated with DEGs were determined by an integrated Pathway Tools software V26.0.