TABLE 4.
Comparison of the sensitivity and specificity of the Aspergillus IgG LFA and ELISAa
| Parameter | LFA | ELISA | P |
|---|---|---|---|
| Specificity, % (n/total) | |||
| Non-CPAb (n = 55) | 92.7 (51/55) | 89.1 (49/55) | 0.507 |
| Sensitivity, % (n/total) | |||
| CPA (n = 116) | 54.3 (63/116) | 55.2 (64/116) | 0.895 |
| A. fumigatus (n = 39) | 87.2 (34/39) | 74.4 (29/39) | 0.151 |
| non-A. fumigatusc (n = 12) | 8.3 (1/12) | 66.7 (8/12) | 0.009 |
| CCPAd (n = 53) | 75.5 (40/53) | 67.9 (36/53) | 0.388 |
| CNPA (n = 20) | 55.0 (11/20) | 75.0 (15/20) | 0.185 |
| SA (n = 11) | 27.3 (3/11) | 36.4 (4/11) | 1.000 |
| AN (n = 32) | 28.1 (9/32) | 28.1 (9/32) | 1.000 |
LFA, lateral flow assay; ELISA, enzyme-linked immunosorbent assay; CPA, chronic pulmonary aspergillosis; CCPA, chronic cavitary pulmonary aspergillosis; CNPA, chronic necrotizing pulmonary aspergillosis; SA, simple aspergilloma; AN, Aspergillus nodule. P was calculated using Pearson’s chi-squared test or Fisher’s exact test, as appropriate.
Non-CPA controls included diseased patients with cryptococcosis (n = 27), mucormycosis (n = 9), mycobacterial lung disease (n = 5), lung cancer (n = 4), nocardiosis (n = 3), penicilliosis (n = 2), histoplasmosis (n = 2), chromomycosis (n = 1), coccidioidomycosis (n = 1), and actinomycosis (n = 1).
Non-A. fumigatus cases included 2 A. flavus and 10 A. niger.
Two patients diagnosed with chronic fibrosing pulmonary aspergillosis were included.