TABLE 1.
In vitro susceptibilities and MICs (mg/L) of cefiderocol and aztreonam-avibactam against carbapenemase-producing Enterobacteriaceae
| Carbapenemase type and bacteria species | AMKc | ATM | CIP | COL | TGC | Cefiderocol |
Aztreonam-avibactama |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S (%) | S (%) | S (%) | I (%) | S (%) | MIC range | MIC50 | MIC90 | S (%) | MIC range | MIC50 | MIC90 | S (%) | |
| MBL (n = 143) | 92.3 | 26.8 | 30.8 | 92.3 | 98.6 | ≤0.06–>32 | 2 | 8 | 86.0 | ≤0.06–16 | 0.25 | 1 | 95.8 |
| NDM (n = 74) | 90.5 | 18.9 | 12.2 | 93.2 | 100 | 0.25–>32 | 2 | 16 | 78.4 | ≤0.06–16 | 0.25 | 4 | 93.2 |
| E. coli (n = 22) | 95.5 | 18.2 | 4.5 | 100 | 100 | 0.5–16 | 4 | 16 | 72.7 | ≤0.06–16 | 2 | 8 | 77.3 |
| ECC (n = 31) | 100 | 3.2 | 6.5 | 100 | 100 | 1–>32 | 2 | 16 | 77.4 | ≤0.06–1 | 0.25 | 0.5 | 100 |
| K. pneumoniae (n = 14) | 78.6 | 42.9 | 35.7 | 85.7 | 100 | 0.5–8 | 1.5 | 4 | 92.9 | ≤0.06–1 | 0.188 | 0.5 | 100 |
| Other speciesb (n = 7) | 57.1 | 42.9 | 14.3 | 57.1 | 100 | 0.25–32 | 4 | 32 | 71.4 | ≤0.06–0.5 | 0.25 | 0.5 | 100 |
| IMP (n = 42) | 95.2 | 51.2 | 52.4 | 92.9 | 95.2 | ≤0.06–32 | 0.375 | 4 | 92.9 | ≤0.06–0.5 | 0.125 | 0.5 | 100 |
| E. coli (n = 17) | 94.1 | 62.5 | 52.9 | 100 | 100 | ≤0.06–4 | 0.25 | 4 | 100 | ≤0.06–0.5 | 0.125 | 0.5 | 100 |
| ECC (n = 13) | 92.3 | 30.8 | 53.8 | 76.9 | 92.3 | ≤0.06–32 | 1 | 16 | 76.9 | ≤0.06–0.5 | 0.125 | 0.5 | 100 |
| K. pneumoniae (n = 5) | 100 | 100 | 100 | 100 | 80.0 | ≤0.06–0.25 | 0.06 | 0.25 | 100 | ≤0.06–0.25 | 0.125 | 0.25 | 100 |
| Other speciesb (n = 7) | 100 | 28.6 | 42.9 | 100 | 100 | ≤0.06–4 | 0.5 | 4 | 100 | ≤0.06–0.5 | 0.125 | 0.5 | 100 |
| VIM (n = 27) | 92.6 | 11.1 | 48.1 | 88.9 | 100 | ≤0.06–8 | 1 | 4 | 96.3 | ≤0.06–16 | 0.25 | 0.25 | 96.3 |
| E. coli (n = 4) | 100 | 25.0 | 50.0 | 100 | 100 | ≤0.06–2 | 0.313 | 2 | 100 | ≤0.06–16 | 0.188 | 16 | 75.0 |
| K. pneumoniae (n = 21) | 90.5 | 9.5 | 47.6 | 85.7 | 100 | ≤0.06–8 | 1 | 4 | 95.2 | ≤0.06–0.5 | 0.25 | 0.25 | 100 |
| Other speciesb (n = 2) | 100 | 0.0 | 50.0 | 100 | 100 | 0.5–2 | 1.25 | 2 | 100 | ≤0.06–0.25 | 0.155 | 0.25 | 100 |
| KPC (n = 38) | 94.7 | 2.6 | 5.3 | 71.1 | 100 | ≤0.06–16 | 0.75 | 4 | 92.1 | ≤0.06–4 | 0.5 | 1 | 100 |
| OXA-48-like (n = 14) | 85.7 | 21.4 | 7.1 | 85.7 | 100 | ≤0.06–16 | 0.75 | 4 | 92.9 | ≤0.06–2 | 0.25 | 1 | 100 |
| Total (n = 195) | 92.3 | 21.6 | 24.1 | 87.7 | 99.0 | ≤0.06–>32 | 1 | 8 | 87.7 | ≤0.06–16 | 0.25 | 1 | 96.9 |
a
Avibactam was tested at a fixed concentration of 4 mg/L.
b
Other species included nine Citrobacter freundii, six Klebsiella oxytoca, and one Klebsiella aerogenes.
c
AMK, amikacin; ATM, aztreonam; CIP, ciprofloxacin; COL, colistin; ECC, Enterobacter cloacae complex; I, intermediate; MBL, metallo-β-lactamase; MIC, minimum inhibitory concentration; S, susceptibility; TGC, tigecycline.