TABLE 1.
Clinical characteristics of the study cohorta
| Featureb | NP group (n = 35) | FGR group (n = 35) | P value |
|---|---|---|---|
| Maternal feature | |||
| Age (yr) | 29.0 (26.0−33.0) | 29.2 (27.0−32.0) | 0.653 |
| Gestational age (w) | 39.5 (39.0−41.0) | 38.0 (36.5−38.5) | <0.001 |
| Wt (kg) | 66.2 (62.1−72.1) | 64.5 (55.9−68.6) | 0.0826 |
| Ht (cm) | 158 (155−160) | 156 (153−158) | 0.0797 |
| BMI (kg/m2) | 27.03 ± 3.13 | 25.97 ± 3.74 | 0.203 |
| G | 2 (1−3) | 2 (1−2) | 0.1077 |
| P | 1 (0−1) | 0 (0−1) | 0.0121 |
| SBP (mmHg) | 117 (112−126) | 127 (121−138) | 0.001 |
| DBP (mmHg) | 71 (64−75) | 75 (70−85) | 0.0017 |
| PLT (×109/L) | 231.0 ± 58.0 | 243.5 ± 59.6 | 0.3797 |
| ALT (U/L) | 10.1 (8−12) | 12.8 (9.0−18.2) | 0.0041 |
| AST (U/L) | 14.5 (12.7−17.4) | 19 (14.1−22.3) | <0.001 |
| ALP (U/L) | 156 (123−173) | 136 (111−179) | 0.2289 |
| ALB (g/L) | 36.29 ± 2.043 | 34.85 ± 3.750 | 0.0496 |
| TBA (μmol/L) | 3.4 (2.6−6.5) | 3.1 (2.4−5.8) | 0.7326 |
| TBil (μmol/L) | 8.0 (7.0−9.7) | 6.9 (5.5−8.1) | 0.0038 |
| DBil (μmol/L) | 1.4 (1.1−1.9) | 1.3 (1.1−1.9) | 0.4233 |
| Cr (μmol/L) | 45.0 (43.0−49.0) | 51.0 (42.0−59.0) | 0.0509 |
| Fetal feature | |||
| Fetal gender | 0.6145 | ||
| Male | 22 | 24 | |
| Female | 13 | 11 | |
| NW (g) | 3,270 (3,020−3,590) | 2,120 (1,950−2,420) | <0.0001 |
| BPD (mm) | 92.0 (86.0−95.0) | 81.0 (75.0−86.0) | <0.0001 |
| HC (mm) | 329 (317−335) | 296 (274−307) | <0.0001 |
| AC (mm) | 337 (325−345) | 280 (257−292) | <0.0001 |
| FL (mm) | 72 (69−73) | 62 (58−66) | <0.0001 |
| AFV (mm) | 48 (42−55) | 38 (30−45) | 0.0028 |
Data were assessed for normality using the Shapiro-Wilk normality test and presented as mean ± SD or median (interquartile range). For normally distributed data, Student's t test was performed between two groups. For nonnormal distributed data, Mann-Whitney U test was performed. For the comparison of fetal gender, chi-square test was conducted.
BMI, body mass index; G, gravidity; P, parity; SBP, systolic blood pressure; DBP, diastolic blood pressure; PLT, platelet; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; ALB, albumin; TBil, total bilirubin; DBil, direct bilirubin; Cr, creatinine; NW, neonatal weight; BPD, biparietal diameter; HC, head circumference; AC, abdominal circumference; FL, femur length; AFV, amniotic fluid volume.