TABLE 1.

Virus yield per cell in CTB cells and M2 differentiated macrophages infected with ZIKV-MR77, ZIKV-MEX, DENV-2, and the YFV-17D vaccine strain at different times postinfection^a

Cell type and virus	Time (hpi)	VPb/cell	Fold change vs:
			ZIKV-MR77	ZIKV-MEX	DENV-2	YFV-17D
CTB cells
ZIKV-MR77	24	18	1	3.6	2	6
	48	275	1	4.4	22	19.6
	72	194	1	3.4	17.6	10.8
	96	196	1	3.7	28	11.5
ZIKV-MEX	24	5		1	0.5	1.7
	48	63		1	5.3	4.5
	72	57		1	5.2	3.2
	96	53		1	7.6	3.1
DENV-2	24	9			1	3
	48	12			1	0.9
	72	11			1	0.6
	96	7			1	0.4
YFV-17D	24	3				1
	48	14				1
	72	18				1
	96	17				1
M2-Mϕs
ZIKV-MR77	24	653	1	4.6	4.6	4.9
	48	3,382	1	2.7	3.2	4.4
	72	4,527	1	3.0	3.9	5.4
	96	4,933	1	3.2	4.1	5.7
ZIKV-MEX	24	141		1	1	1.1
	48	1,253		1	1.2	1.6
	72	1,510		1	1.3	1.8
	96	1,543		1	1.3	1.8
DENV-2	24	143			1	1.1
	48	1,055			1	1.4
	72	1,162			1	1.4
	96	1,215			1	1.4
YFV-17D	24	134				1
	48	766				1
	72	846				1
	96	866				1

^aShown are the virus yield per cell in cytotrophoblastic (CTB) cells and M2 differentiated macrophages (M2-Mϕs) infected with ZIKV-MR77 (African lineage), ZIKV-MEX (Asian lineage), DENV-2, and the YFV-17D vaccine strain, calculated at different 24, 48, 72, 96 hpi. Fold differences among viruses are indicated.

^bVP viral particles.