TABLE 1.
Susceptibility of P. aeruginosa isolates to antibiotics by time period
| 1999–2002 | OR and P-Value | 2003–2009 | 2017–2019 | OR and P-value | |
|---|---|---|---|---|---|
| n = 93 | n = 101 | n = 33 | |||
| Piperacillin-Tazobactam | |||||
| Suscb | 65 (70%) | OR = 0.80 | 75 (74%) | 22 (79%) | OR = 1.27 |
| NS | 28 (30%) | p = 0.498 | 26 (26%) | 6 (21%) | p = 0.641 |
| Cefepime | |||||
| Susc | 63 (72%) | OR = 0.47 | 85 (84%) | 26 (79%) | OR = 0.70 |
| NS | 24 (28%) | p = 0.039 | 16 (16%) | 7 (21%) | p = 0.479 |
| Meropenem | |||||
| Susc | 67 (73%) | OR = 1.62 | 63 (62%) | 26 (79%) | OR = 1.71 |
| NS | 25 (27%) | p = 1.54 | 38 (38%) | 7 (21%) | p = 0.08 |
| Ciprofloxacin | |||||
| Susc | 53 (57%) | OR = 0.87 | 61 (60%) | 23 (70%) | OR = 1.51 |
| NS | 40 (43%) | p = 0.63 | 40 (40%) | 10 (30%) | p = 0.34 |
| Amikacin | |||||
| Susc | 88 (95%) | OR = 0.95 | 93 (95%) | 31 (94%) | OR = 0.83 |
| NS | 5 (5.4%) | p = 0.932 | 5 (5%) | 2 (6.1%) | p = 0.83 |
| Tobramycin | |||||
| Susc | 81 (87%) | OR = 1.08 | 87 (86%) | 28 (88%) | OR = 1.13 |
| NS | 12 (13%) | p = 0.85 | 14 (14%) | 4 (12%) | p = 0.85 |
| Gentamicin | |||||
| Susc | 68 (73%) | OR = 0.40 | 88 (87%) | 25 (78%) | OR = 0.53 |
| NS | 25 (27%) | p = 0.016 | 13 (13%) | 7 (22%) | p = 0.22 |
| Colistin | |||||
| Susc | 86 (98%) | OR = 18.4 | 70 (70%) | 27 (82%) | OR = 1.92 |
| NS | 2 (2%) | p < 0.001 a | 30 (30%) | 6 (18%) | p = 0.19 |
a
P-values bolded indicate significance as calculated by logistic regression. The referent range is 2003–2009.
b
Not all numbers add up to the total number of isolates in each collection, as susceptibility data were unavailable for some isolates. Susc = Susceptible; NS = Nonsusceptible.