TABLE 2.
AME genes present in P. aeruginosa isolates
| No. of Isolates with AME Gene (% of Isolates) | ||||||
|---|---|---|---|---|---|---|
| Gene | Protein | Activitya | 1999–2002 | 2003–2009 | 2017–2019 | Total |
| (n = 93) | (n = 101) | (n = 33) | (n = 227) | |||
| aac(3)-Id | AAC(3)-Id | gent | 1 (1%) | 0 (0%) | 0 (0%) | 1 (0.4%) |
| aac(3)-IIIb | AAC(3)-IIIb | gent, tob, kan | 0 (0%) | 2 (2%) | 0 (0%) | 2 (0.9%) |
| aac(6′)-Ib | AAC(6’)-Ib | tob, kan | 1 (1%) | 3 (3%) | 0 (0%) | 4 (2%) |
| aac(6′)-Ib' | AAC(6’)-Ib’ | gent, tob | 3 (3%) | 0 (0%) | 0 (0%) | 3 (1%) |
| aac(6′)-II | AAC(6)-II | gent, tob | 1 (1%) | 0 (0%) | 0 (0%) | 1 (0.4%) |
| aac(6′)-IIc | AAC(6’)-IIc | gent, tob, kan | 0 (0%) | 1 (1%) | 0 (0%) | 1 (0.4%) |
| aadA1 | ANT(3″)-Ia | strep | 0 (0%) | 2 (2%) | 0 (0%) | 2 (0.9%) |
| aadA2 | ANT(3″)-Ia | strep | 4 (4%) | 0 (0%) | 0 (0%) | 4 (2%) |
| aadA6 | ANT(3″)-Ia | strep | 4 (4%) | 5 (5%) | 1 (3%) | 10 (4%) |
| aadA7 | ANT(3″)-Ia | strep | 0 (0%) | 3 (3%) | 0 (0%) | 3 (1%) |
| aadA10 | ANT(3″)-Ia | strep | 4 (4%) | 3 (3%) | 1 (3%) | 8 (4%) |
| ant(2″)-Ia | ANT(2″)-Ia | gent, tob | 8 (9%) | 4 (4%) | 1 (3%) | 13 (6%) |
| aph(3′)-Ib | APH(3′)-Ib | kan, neo | 0 (0%) | 1 (1%) | 0 (0%) | 1 (0.4%) |
| aph(3′)-IIb | APH(3′)-IIb | kan, neo | 93 (100%) | 101 (100%) | 33 (100%) | 227 (100%) |
| aph(3″)-Ib | APH(3″)-Ib | strep | 1 (1%) | 0 (0%) | 0 (0%) | 1 (0.4%) |
| aph(6)-Id | APH(6)-Id | strep | 1 (1%) | 0 (0%) | 0 (0%) | 1 (0.4%) |
| Isolates with at least 1 AME geneb | 16 (17%) | 14 (14%) | 2 (6%) | 32 (14%) | ||