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. 2023 May 22;11(3):e00302-23. doi: 10.1128/spectrum.00302-23

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Copyright © 2023 Wu et al.

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FIG 2 — METH exposure altered the gut microbiota metabolome. (A) PCA plot of fecal metabolites in ES⁺. (B) PCA plot of fecal metabolites in ES⁻. (C) PLS-DA analysis of fecal metabolites in ES⁺. (D) PLS-DA analysis of fecal metabolites in ES⁻. (E) Different fecal metabolites between the METH and saline group in ES⁺ (top 30 results). (F) Different fecal metabolites between the METH and saline group in ES⁻ (top 30 results). (G) Metabolites which showed significant correlation with critical microbiota taxa in ES⁺. (H) Metabolites which showed significant correlation with critical microbiota taxa in ES⁻. n = 6 for each group. *, P < 0.05; **, P < 0.01; ***, P < 0.001.