Table 4.
Clinical outcome analysis with propensity score-matched cohorts.
| Outcomes | Low-CVP | High-CVP | p-value |
|---|---|---|---|
| Primary outcome | |||
| 28-day mortality | 11/1,046 (1.05) | 37/1,046 (3.54) | <0.001*** |
| Secondary outcomes | |||
| In-hospital mortality | 15/1,046 (1.43) | 41/1,046 (3.92) | <0.001*** |
| 1-year mortality | 31/1,046 (2.96) | 54/1,046 (5.16) | 0.014* |
| Length of ICU stay (days) | 2.09 (1.26–3.46) | 2.39 (1.34–4.47) | <0.001*** |
| Length of hospitalization (days) | 7.85 (5.67–11.79) | 8.71 (5.93–12.92) | 0.006** |
| AKI within 7 days, n (%) | 337/1,046 (32.22) | 425/1,046 (40.63) | <0.001*** |
| RRT, n (%) | 29/1,046 (2.77) | 45/1,046 (4.30) | 0.075 |
| Vasopressor, n (%) | 889/1,046 (84.99) | 967/1,046 (92.45) | <0.001*** |
| Inotropes, n (%) | 321/1,046 (30.69) | 386/1,046 (36.90) | 0.031** |
| Maximum of lactate level on day 1 (mmol/L) | 3.02 (0.05) | 3.42 (0.06) | <0.001*** |
| Lactate clearance on day 1 (%) | 15.99 (1.88) | 9.20 (2.43) | 0.033* |
| Duration of ventilation (h) | 6.00 (3.82–16.00) | 12.50 (5.00–23.13) | <0.001*** |
| PO2/FiO2 (mmHg) | 182 (133–242) | 170 (117–232) | <0.001*** |
| Fluid balance on day 1 (L) | 9.10 (0.12) | 10.03 (0.16) | <0.001*** |
| Fluid balance on day 2 (L) | 0.71 (0.08) | 1.10 (0.10) | 0.044* |
CVP, central venous pressure; ICU, intensive care unit; AKI, acute kidney injury; RRT, renal replacement therapy; PO2, partial pressure of oxygen; FiO2, fraction of inspiration oxygen.
*p<0.05; **p<0.01; ***p<0.001.