TABLE 2.
Strain characteristicsa
| Patient no. | French reference center ID of isolate | Animal species | Age (yrs) | Breed | Sex | French administrative departmentd | Monoinfection | Symptoms | Species | Toxin gene | Elek test | Sequence type | Antibiotic susceptibility test result for indicated group and drugb |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aminoglycosides, gentamicin | Beta-lactams, amoxicillin | Macrolides Erythromycin | Spiramycin | Azithromycin | Tetracyclines, tetracycline and doxycycline | Folate pathway inhibitors, trimethoprim-sulfamethoxazole | |||||||||||||
| 1 | FRC0804 | Cat | 11 | Domestic shorthair | F | 57 | No | Chronic rhinitis | C. ulcerans | Positive | Positive | ST514 | S | S | S | S | S | S | S |
| 3 | FRC0847 | Cat | 7 | Domestic shorthair | F | 26 | Yes | Chronic rhinitis | C. ulcerans | Positive | Weakly Positive | ST325 | S | S | S | S | S | S | S |
| 5 | FRC0886 | Rat | 0.9 | ND | ND | 40 | No | Chronic rhinitis | C. ulcerans | Positive | Positive | ST332 | I | S | S | S | NA | S | S |
| 6 | FRC0895 | Rat | 1 | ND | M | 40 | No | Chronic rhinitis | C. ulcerans | Positive | NA | NA (contaminated) | S | S | S | NA | NA | S | S |
| 7 | FRC0897 | Cat | ND | Domestic shorthair | M | 41 | Yes | Chronic rhinitis + FIV | C. ulcerans | Positive | Positive | ST757 | S | S | S | S | S | S | S |
| 8 | FRC0916 | Dog | 6 | Mastiff | M | 78 | No | Sore/abscess | C. ulcerans | Positive | Positive | ST325 | S | S | S | S | S | S | S |
| 9 | FRC0922 | Cat | 1 | Domestic shorthair | F | 64 | No | Dermatitis | C. ulcerans | Positive | Positive | ST699 | S | S | S | S | S | S | S |
| 10 | FRC0929 | Dog | 3 | Basset Bleu De Gascogne | F | 71 | Yes | Sore | C. ulcerans | Positive | Positive | ST328 | S | S | S | S | S | S | S |
| 11 | FRC1009 | Dog | 3 | French bulldog | F | 17 | Yes | Chronic otitis | C. ulcerans | Positive | Positive | ST331 | S | S | S | S | S | S | S |
| 12 | FRC1027 | Cat | 8 | Domestic shorthair | M | 60 | No | Chronic otitis | C. ulcerans | Positive | Weakly Positive | ST325 | S | S | S | S | S | S | S |
| 13 | FRC1031 | Dog | 5 | German shepherd | M | 16 | No | Chronic otitis | C. ulcerans | Positive | Positive | ST331 | S | S | S | S | S | S | S |
| 14 | FRC1067 | Dog | 2 | Belgian shepherd | M | 62 | Yes | Abscess | C. ulcerans | Positive | Positive | ST331 | S | S | S | S | S | S | S |
| 15 | FRC1084 | Dog | 9 | Xc Lhasa Apso | F | 57 | No | Dermatitis | C. ulcerans | Positive | Positive | ST328 | I | S | S | S | S | S | S |
| 16 | FRC1089 | Dog | 7 | Chow chow | F | 06 | No | Chronic otitis | C. ulcerans | Positive | Weakly Positive | ST325 | I | S | S | S | S | S | S |
| 17 | FRC1102 | Cat | 13 | Domestic shorthair | M | 13 | No | Chronic rhinitis | C. ulcerans | Positive | Positive | ST325 | S | S | S | S | S | S | S |
| 18 | FRC1111 | Cat | 8 | Domestic shorthair | M | 77 | No | Sore | C. ulcerans | Positive | Positive | ST337 | S | S | S | S | S | S | S |
| 19 | FRC1115 | Dog | 8 | Small Bernese hound | M | 07 | No | Dermatitis | C. ulcerans | Positive | Positive | ST690 | I | S | S | S | S | S | S |
| 20 | FRC1123 | Dog | 7 | Jack Russell terrier | M | 42 | No | Sore | C. ulcerans | Positive | Negative | ST331 | I | S | S | S | S | S | S |
| 21 | FRC1127 | Rabbit | 0.8 | ND | F | 60 | No | Chronic rhinitis | C. ulcerans | Positive | Negative | ST358 | S | S | S | S | S | S | S |
| 22 | FRC1128 | Dog | 1 | Cane Corso | F | 12 | Yes | Chronic rhinitis | C. ulcerans | Positive | Positive | ST325 | S | S | S | S | S | S | S |
| 23 | FRC1137 | Rat | 1 | ND | M | 25 | Yes | Chronic rhinitis | C. ulcerans | Positive | Positive | ST332 | S | S | S | S | S | S | S |
| 24 | FRC1148 | Cat | 15 | Domestic shorthair | F | 78 | No | Chronic rhinitis | C. ulcerans | Positive | Negative | ST331 | I | S | S | S | S | S | S |
| 25 | FRC0855 | Cat | 5 | Domestic shorthair | F | 95 | Yes | Chronic rhinitis | C. ulcerans | Negative | NR | ST325 | S | S | S | S | S | S | S |
| 26 | FRC0856 | Dog | ND | German shepherd | ND | ND | No | Chronic otitis | C. ulcerans | Negative | NR | ST720 | I | S | S | S | S | S | S |
| 28 | FRC0915 | Cat | 1 | Maine Coon | F | 46 | No | Chronic rhinitis | C. ulcerans | Negative | NR | ST339 | S | S | S | S | S | S | S |
| 29 | FRC0921 | Dog | 5 | French mastiff | M | 57 | No | Dermatitis | C. ulcerans | Negative | NR | ST699 | S | S | S | S | S | S | S |
| 30 | FRC0971 | Dog | ND | Griffon | M | 45 | No | Chronic otitis | C. ulcerans | Negative | NR | ST339 | S | S | S | S | S | S | S |
| 31 | FRC0973 | Dog | 9 | Beauceron | F | 47 | No | Chronic otitis | C. ulcerans | Negative | NR | ST760 | S | S | S | S | S | S | S |
| 32 | FRC0981 | Dog | 4 | German shepherd | M | 77 | No | Chronic rhinitis | C. ulcerans | Negative | NR | ST339 | S | S | S | S | S | S | S |
| 34 | FRC0990 | Dog | 6 | German shepherd | M | 69 | No | Chronic rhinitis | C. ulcerans | Negative | NR | ST339 | S | S | S | S | S | S | S |
| 36 | FRC1028 | Dog | 0.3 | Great Dane | F | 77 | No | Dermatitis | C. ulcerans | Negative | NR | ST690 | S | S | S | S | S | S | S |
| 37 | FRC1032 | Cat | 11 | ND | F | 35 | Yes | Cystitis | C. ulcerans | Negative | NR | ST690 | S | S | S | S | S | S | S |
| 38 | FRC1047 | Cat | 17 | Domestic shorthair | F | 64 | No | Sore | C. ulcerans | Negative | NR | ST428 | S | S | S | S | S | S | S |
| 39 | FRC1054 | Cat | 7 | Domestic shorthair | M | 92 | No | Sore | C. ulcerans | Negative | NR | ST339 | S | S | R | R | R | S | S |
| 41 | FRC1110 | Dog | 6 | Cocker spaniel | M | 71 | No | Chronic otitis | C. ulcerans | Negative | NR | ST339 | S | S | S | S | S | S | S |
| 42 | FRC1114 | Cat | 13 | Birman | F | 16 | Yes | Chronic rhinitis | C. ulcerans | Negative | NR | ST325 | I | S | S | S | S | S | S |
| 43 | FRC1134 | Cat | 6 | Porcelaine | F | 45 | No | Chronic rhinitis | C. ulcerans | Negative | NR | ST339 | S | S | S | S | S | S | S |
| 44 | FRC1146 | Dog | 5 | Porcelaine | F | 38 | No | Sore | C. ulcerans | Negative | NR | ST339 | I | S | S | S | S | S | S |
| 45 | FRC1153 | Dog | 4 | Great Dane | F | 59 | No | Sore | C. ulcerans | Negative | NR | ST339 | R | S | S | S | S | S | S |
| 46 | FRC1164 | Dog | 6 | Great Dane | M | 57 | No | Dermatitis | C. ulcerans | Negative | NR | ST327 | S | S | S | S | S | S | S |
| 47 | FRC1165 | Cat | 7 | Domestic shorthair | F | 18 | No | Sore | C. ulcerans | Negative | NR | ST325 | S | S | S | S | S | S | S |
| 48 | FRC1170 | Dog | 9 | German shepherd | M | 13 | No | Chronic rhinitis | C. ulcerans | Negative | NR | ST339 | S | S | S | S | S | S | S |
| 49 | FRC1194 | Dog | 9 | German shepherd | M | 70 | No | Chronic otitis | C. ulcerans | Negative | NR | ST339 | S | S | S | S | S | S | S |
| 50 | FRC1193 | Cat | 7 | Rex Devon | M | 67 | No | Chronic otitis | C. ulcerans | Negative | NR | ST325 | S | S | S | I | S | S | S |
| 51 | FRC0848 | Cat | 13 | Domestic shorthair | M | 17 | No | Chronic otitis | C. ulcerans | Negative | NR | ST720 | S | S | S | S | S | S | S |
| 52 | FRC1017 | Horse | 30 | ND | F | 33 | No | Conjunctivitis | C. diphtheriae | Positive | Positive | ST669 | S | S | S | S | S | S | S |
| 53 | FRC1117 | Horse | 8 | ND | M | 40 | No | Dermatitis | C. diphtheriae | Positive | Positive | ST59 | S | S | S | S | S | S | S |
| 54 | FRC0802 | Dog | 9 | Drahthaar | M | 37 | No | Sore | C. rouxii | Negative | NR | ST694 | I | S | S | S | S | S | S |
| 55 | FRC0810 | Dog | 9 | ND | F | 84 | No | Chronic otitis | C. rouxii | Negative | NR | NA (rpoB truncated) | I | S | S | S | S | S | S |
| 56 | FRC0845 | Dog | ND | Labrador | ND | ND | No | Chronic otitis | C. rouxii | Negative | NR | ST714 | S | S | S | S | S | S | S |
| 57 | FRC0835 | Cat | ND | Domestic shorthair | ND | ND | Yes (+ Malassezia) | Chronic otitis | C. rouxii | Negative | NR | ST713 | S | S | S | S | S | S | S |
| 58 | FRC0926 | Cat | 1 | Domestic shorthair | M | 47 | No | Sore | C. rouxii | Negative | NR | ST537 | I | S | S | S | S | S | S |
| 59 | FRC0976 | Dog | 12 | German shepherd | F | 47 | No | Chronic otitis | C. rouxii | Negative | NR | ST762 | S | S | S | S | S | S | S |
| 60 | FRC1088 | Dog | 6 | American Staffordshire bull terrier | M | 84 | No | Chronic otitis | C. rouxii | Negative | NR | ST537 | I | S | S | S | S | S | S |
| 61 | FRC1100 | Dog | 13 | X Beagle | F | 17 | No | Chronic otitis | C. rouxii | Negative | NR | ST780 | S | S | S | S | S | S | S |
| 62 | FRC1150 | Dog | 7 | X Griffon | F | 64 | No | Chronic otitis | C. rouxii | Negative | NR | ST537 | S | S | S | S | S | S | S |
| 63 | FRC1159 | Dog | 9 | Labrador | M | 33 | No | Chronic otitis | C. rouxii | Negative | NR | ST537 | S | S | S | S | S | S | S |
| 64 | FRC1172 | Dog | 3 | Griffon | M | 65 | No | Chronic otitis | C. rouxii | Negative | NR | ST537 | S | S | S | S | S | S | S |
a
ID, identifier; F, female; M, male; FIV, feline immunodeficiency virus; ND, not documented; NR, not relevant; NA, not available; S, susceptible; I, intermediate; R, resistant.
b
breakpoints: gentamicin, S ≥ 18 and R < 16; amoxicillin, S ≥ 23 and R < 16; erythromycin, S ≥ 22 and R < 17; spiramycin, S ≥ 24 and R < 19; azithromycin, S ≥ 22 and R < 17; tetracycline and doxycycline, S ≥19 and R < 17; trimethoprim-sulfamethoxazole, S ≥ 16 and R < 10.
c
X, mixed breed.