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. 2023 May 1;37(9-10):418–431. doi: 10.1101/gad.350400.123

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Published by Cold Spring Harbor Laboratory Press

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Figure 4. — Maternal eIF4E1b reprograms zygotic chromatin accessibility. (A) Ratio of endogenous methylated CpG among all CpG motifs to show global DNA methylation patterns in PN5 zygotes and early two-cell embryos from Eif4e1b^Het (control) and Eif4e1b^KO females. (B) DNA methylation profile around minor ZGA gene loci in PN5 zygotes and early two-cell embryos from control and Eif4e1b^KO females. (N.S.) Not significant, (*) P < 0.05, (****) P < 0.0001; two-tailed t-test. (C) Same as A, but for global chromatin accessibility using an exogenous GpC methyltransferase (M.CviPI) to methylate accessible GpC. (D) Same as B, but for global chromatin accessibility. (E) Heat map showing chromatin accessibility at promoter regions (left) and expression of corresponding minor ZGA genes (right) in early two-cell embryos. Individual minor ZGA genes are annotated.