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. 2023 Apr 4;10(6):879–891. doi: 10.1002/acn3.51770

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© 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Age‐dependent changes in plasma Aß levels according to APOE genotypes. One‐way analysis of variance models for comparisons of plasma Aβ levels with APOE genotypes between different generations. Aβ40 levels were not affected by the APOE genotype in either generation. Aβ42 levels in the elderly group significantly differed in the APOE‐ε2/ε3 > APOE‐ε3/ε3, APOE‐ε2/ε3 > APOE‐ε3/ε4, and APOE‐ε3/ε3 > APOE‐ε3/ε4 groups. The Aβ40/42 ratio in the middle‐aged group significantly differed in the APOE‐ε3/ε3 > APOE‐ε4/ε4 and APOE‐ε2/ε4 > APOE‐ε4/ε4 groups. The Aβ40/42 ratio in the elderly group was high in the order of APOE‐ε2/ε3 = APOE‐ε3/ε3 > APOE‐ε2/ε4 = APOE‐ε3/ε4.