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. 2023 Apr 4;10(6):879–891. doi: 10.1002/acn3.51770

Table 2.

Results of linear mixed‐effects models including APOE.

Aβ species Aβ40 Aβ42 Aβ40/42 ratio
Linear mixed‐effects models including APOE
Model includes APOE‐ε4 APOE‐ε2 APOE‐ε4 APOE‐ε2 APOE‐ε4 APOE‐ε2
Fixed effect β (SE) P β (SE) P β (SE) P β (SE) P β (SE) P β (SE) P
Intercept 101.10 (2.45) <0.001 101.15 (2.38) <0.001 13.14 (0.35) <0.001 13.19 (0.34) <0.001 7.67 (0.19) <0.001 7.60 (0.18) <0.001
Age 0.35 (0.03) <0.001 0.34 (0.02) <0.001 0.02 (0.004) <0.001 0.01 (0.003) >0.001 0.02 (0.002) <0.001 0.02 (0.002) <0.001
APOE −0.12 (2.88) 0.966 −2.45 (4.26) 0.566 0.39 (0.38) 0.312 −0.13 (0.57) 0.826 −0.40 (0.19) 0.037 −0.03 (0.29) 0.913
eGFR −0.22 (0.02) <0.001 −0.22 (0.02) <0.001 −0.03 (0.003) <0.001 −0.03 (0.003) <0.001 0.002 (0.001) 0.194 0.002 (0.001) 0.163
Age × APOE −0.002 (0.05) 0.977 0.08 (0.08) 0.3041 −0.02 (0.01) 0.028 0.01 (0.01) 0.365 0.01 (0.004) <0.001 −0.002 (0.01) 0.752

Aβ, amyloid‐beta; SE, standard error; eGFR, estimated glomerular filtration rate.

β is the fixed effect and P is the P‐value. “×” indicates an interaction between two variables.