Table 2.
Results of linear mixed‐effects models including APOE.
Aβ species | Aβ40 | Aβ42 | Aβ40/42 ratio | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Linear mixed‐effects models including APOE | ||||||||||||
Model includes | APOE‐ε4 | APOE‐ε2 | APOE‐ε4 | APOE‐ε2 | APOE‐ε4 | APOE‐ε2 | ||||||
Fixed effect | β (SE) | P | β (SE) | P | β (SE) | P | β (SE) | P | β (SE) | P | β (SE) | P |
Intercept | 101.10 (2.45) | <0.001 | 101.15 (2.38) | <0.001 | 13.14 (0.35) | <0.001 | 13.19 (0.34) | <0.001 | 7.67 (0.19) | <0.001 | 7.60 (0.18) | <0.001 |
Age | 0.35 (0.03) | <0.001 | 0.34 (0.02) | <0.001 | 0.02 (0.004) | <0.001 | 0.01 (0.003) | >0.001 | 0.02 (0.002) | <0.001 | 0.02 (0.002) | <0.001 |
APOE | −0.12 (2.88) | 0.966 | −2.45 (4.26) | 0.566 | 0.39 (0.38) | 0.312 | −0.13 (0.57) | 0.826 | −0.40 (0.19) | 0.037 | −0.03 (0.29) | 0.913 |
eGFR | −0.22 (0.02) | <0.001 | −0.22 (0.02) | <0.001 | −0.03 (0.003) | <0.001 | −0.03 (0.003) | <0.001 | 0.002 (0.001) | 0.194 | 0.002 (0.001) | 0.163 |
Age × APOE | −0.002 (0.05) | 0.977 | 0.08 (0.08) | 0.3041 | −0.02 (0.01) | 0.028 | 0.01 (0.01) | 0.365 | 0.01 (0.004) | <0.001 | −0.002 (0.01) | 0.752 |
Aβ, amyloid‐beta; SE, standard error; eGFR, estimated glomerular filtration rate.
β is the fixed effect and P is the P‐value. “×” indicates an interaction between two variables.