Table 3.

Results of the change point analysis and mixed‐effects models including change points and APOE.

Aβ species	Aβ40	Aβ42	Aβ40/42 ratio
CP (95% CI)	38.2 (36.7–39.6)	36.4 (34.1–38.6)	43.5 (36.3–50.7)
Former/latter slope of CP (95% CI)	−0.79 (−1.02 to −0.55)/0.52 (0.46 to 0.58)	−0.10 (−0.14 to −0.06)/0.03 (0.02 to 0.03)	0.01 (−0.07 to 0.02)/0.03 (0.02 to 0.03)

Mixed effect models including change points and APOE
Model includes	APOE‐ε4		APOE‐ε2		APOE‐ε4		APOE‐ε2		APOE‐ε4		APOE‐ε2
Fixed effect	β (SE)	P	β (SE)	P	β (SE)	P	β (SE)	P	β (SE)	P	β (SE)	P
Intercept	128.93 (2.69)	<0.001	126.32 (2.60)	<0.001	15.40 (0.40)	<0.001	15.21 (0.38)	<0.001	8.41 (0.19)	<0.001	8.33 (0.19)	<0.001
Age (former CP)	−17.49 (2.10)	<0.001	−14.26 (1.95)	<0.001	−1.88 (0.31)	<0.001	−1.71 (0.29)	<0.001	−0.01 (0.14)	0.96	0.12 (0.13)	0.344
Age (latter CP)	12.09 (2.10)	<0.001	13.42 (1.98)	<0.001	−0.16 (0.31)	0.614	−0.27 (0.29)	0.358	1.23 (0.14)	<0.001	1.44 (0.13)	<0.001
APOE	−9.85 (3.98)	0.013	9.36 (6.18)	0.13	−0.54 (0.60)	0.37	1.27 (0.94)	0.177	−0.25 (0.23)	0.287	−0.15 (0.35)	0.669
eGFR	−0.24 (0.02)	<0.001	−0.24 (0.02)	<0.001	−0.03 (0.003)	<0.001	−0.03 (0.003)	<0.001	0.001 (0.002)	0.425	0.002 (0.002)	0.339
Age × APOE (former CP)	12.20 (4.57)	0.008	−11.40 (7.29)	0.118	0.51 (0.68)	0.455	−1.30 (1.08)	0.228	0.50 (0.28)	0.08	0.07 (0.44)	0.878
Age × APOE (latter CP)	6.47 (4.32)	0.134	−1.08 (6.47)	0.868	−0.68 (0.63)	0.286	−0.23 (0.96)	0.809	1.07 (0.28)	<0.001	−0.10 (0.41)	0.801

Aβ, amyloid‐beta; SE, standard error; CP, change point; eGFR, estimated glomerular filtration rate.