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Schematic representation of LRRK2 gene and LRRK2 protein with its functional domains. LRRK2 pathogenic variants are indicated in red, risk variants in light blue, the protective haplotype in green. aa, amino acids; ANK, ankyrin repeat region; ARM, armadillo repeat region; Bp, base pairs; COR, C‐terminal‐of‐Roc domain; Kinase, protein tyrosine kinase‐like domain; LRR, leucine‐rich repeats; ROC, ras‐of‐complex GTPase domain; WD40, WD40 repeat region.
