Figure 2.

Photomicrographs of a 75-year-old male SERPINA5 p.E228Q carrier neuropathologically diagnosed with Alzheimer’s disease. Representative images of the locus coeruleus, entorhinal cortex, limbic structures (CA1 hippocampal subsector), association cortices (superior temporal), and primary cortices (visual) are shown. Case characteristics – disease duration = 6 years, Braak tangle stage = VI, Thal phase = 5, and TDP-43 positive. Immunohistochemistry–SERPINA5 and tau (early tangle marker: AT8, advanced tangle marker: 2E9). Scale bar–50μm.