Table 1. .
Demography, disease severity, and cognitive status
| Group | n | Age | Sex (% of females) | Education | CDR | MMSE |
|---|---|---|---|---|---|---|
| HCtotal | 99 | 66.0 (4.45) | 54.5 | 18.0 (2.97) [4] | 0 (0.0) [31] | 30.0 (0) |
| HCsub1 | 50 | 63.0 (5.19) | 46 | 16.0 (1.48) [1] | 0 (0.0) [31] | 29.0 (1.48) |
| HCsub2 | 50 | 68.0 (5.93) | 58 | 17.0 (1.48) [2] | 0 (0.0) [11] | 29.5 (0.74) |
| bvFTD | 47 | 62.0 (5.93) | 38.3 | 15.5 (3.71) | 1 (0.74) | 25.0 (4.45) |
| CBS | 38 | 67.0 (8.15) | 52.6 | 16.0 (2.97) [2] | 0.5 (0.37) [2] | 25.0 (4.45) [4] |
| nfvPPA | 34 | 69.5 (8.90) | 52.9 | 16.0 (2.97) | 0.5 (0.0) [1] | 26.0 (2.97) |
| PSP | 42 | 68.5 (6.67) | 50 | 16.0 (2.97) [2] | 0.5 (0.74) [3] | 26.0 (2.97) [4] |
| svPPA | 38 | 64.0 (7.41) | 44.7 | 16.0 (2.97) [1] | 1.0 (0.37) | 24.5 (3.71) [1] |
| Shapiro–Wilk normality test | p = 0.264 | — | p < 0.001 | p < 0.001 | p < 0.001 | |
| Significant between-group comparisons | a, b, c | a, d | d |
Note. Descriptive statistics are presented as the median (median absolute deviation) [missing values]. The HCsub1 subsample is demographically matched with the bvFTD and svPPA groups, and the HCsub2 subsample is matched with the CBS, nfvPPA, and PSP variant groups. Group median comparisons were based on a 5,000 permutations test to deal with tied values (Wilcox, 2017); see details in Supporting Information Table S1. The p values were set at 0.05 and adjusted by the Bonferroni method. a: bvFTD vs. nfvPPA; b: bvFTD vs. PSP; c: PSP vs. svPPA; d: all variant groups presented statistically significant differences to the HC group. bvFTD = behavioral variant of FTD; CBS = corticobasal syndrome; CDR = Clinical Dementia Rating; HC = healthy controls; MMSE = Mini-Mental State Exam; nfvPPA = nonfluent variant primary progressive aphasia; PSP = progressive supranuclear palsy; svPPA = semantic variant primary progressive aphasia.