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. Author manuscript; available in PMC: 2023 Jun 15.
Published in final edited form as: J Med Chem. 2023 Mar 22;66(7):4617–4632. doi: 10.1021/acs.jmedchem.2c01548

Table 1.

Substitution in the hydrophilic pocket

graphic file with name nihms-1903761-t0014.jpg

IC50 values are reported as mean ± SEM of two experiments. Each experiment has three independent biological replicates. NE means no effect (IC50 > 10,000 nM).