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. 2023 Jun 16;112:188–205. doi: 10.1016/j.bbi.2023.06.015

Fig. 1.

Fig. 1

SARS-CoV-2 infection occurs in the brain of pregnant mice. (A) Experimental schematic. (B-C) RT-qPCR data showing viral load of SARS-CoV-2 in the brain shows significant infection in infected pregnant mice compared to mock at E14.5 and E18.5, respectively. n = 3–4. (D) Viral detection is seen in fetal brains at the later time point of E18.5, and is significantly higher in male fetuses than females. n = 6–10. (E) Significant S protein is detected in whole fetal brains via imaging flow cytometry data at E18.5.