Table 3.
Association of BMI with serum and RBC folate, stratified by MTHFR 677C→T genotype and folic acid supplementation‡; pregnant women (n 869) recruited between 12 and 20 weeks of gestation, Ottawa and Kingston (OaK) Birth Cohort study, April 2008–April 2009
| Serum folate‡ | RBC folate‡ | |||||
|---|---|---|---|---|---|---|
| β | 95 % CI | P | β | 95 % CI | P | |
| All participants§ | −0·32 | −0·50, −0·16 | <0·001 | 0·14 | 0·05, 0·22 | 0·001 |
| MTHFR 677C→T genotype|| | ||||||
| CC | −0·42 | −0·66, −0·17 | <0·001 | 0·19 | 0·06, 0·32 | 0·003 |
| CT | −0·25 | −0·49, −0·02 | 0·037 | 0·10 | −0·02, 0·22 | 0·107 |
| TT | −0·16 | −0·64, 0·32 | 0·521 | 0·10 | −0·16, 0·36 | 0·449 |
| Folic acid supplementation|| | ||||||
| Non-users | −0·62 | −1·09, −0·14 | 0·011 | 0·44 | −0·12, 1·00 | 0·124 |
| ≤1 mg/d | −0·32 | −0·48, −0·16 | <0·001 | 0·12 | 0·02, 0·22 | 0·015 |
| >1 mg/d | −0·21 | −0·78, 0·37 | 0·478 | 0·22 | 0·03, 0·41 | 0·021 |
RBC, red blood cell; MTHFR, methylenetetrahyrofolate reductase gene; β, the partial regression coefficient of log-transformed BMI.
BMI, serum folate and RBC folate concentrations were log-transformed.
Regression coefficient of BMI in all participants, adjusted for MTHFR 677C→T genotype, folic acid supplementation, age, gestational age at recruitment, race, maternal education, household annual income and smoking.
Regression coefficient of BMI in subgroups stratified by MTHFR 677C→T genotype or folic acid supplementation, adjusted for age, gestational age at recruitment, race, maternal education, household annual income and smoking.