Table 3.
Spearman correlations between total cruciferous vegetable intake and blood as well as tissue biomarkers among women at high risk for breast cancer participating in a randomized clinical trial
| Total cruciferous vegetable intake (g/d) | |||||
|---|---|---|---|---|---|
| Biomarker | n | Crude correlation, r | Crude correlation, P value | Partial correlation, r | Partial correlation, P value* |
| PBMC HDAC activity | 48 | 0·25 | 0·09 | 0·23 | 0·12 |
| H3K18ac | |||||
| Benign | 15 | −0·46 | 0·08 | −0·39 | 0·19 |
| DCIS | 10 | 0·15 | 0·68 | 0·38 | 0·35 |
| IDC | 10 | 0·00 | 1·00 | 0·09 | 0·83 |
| H3K9ac | |||||
| Benign | 32 | 0·28 | 0·12 | 0·26 | 0·16 |
| DCIS | 16 | −0·06 | 0·83 | 0·12 | 0·69 |
| IDC | 11 | −0·03 | 0·93 | 0·08 | 0·83 |
| HDAC3 | |||||
| Benign | 27 | −0·14 | 0·50 | −0·13 | 0·54 |
| DCIS | 7 | 0·66 | 0·11 | −0·43 | 0·47 |
| IDC | 2 | na | na | na | na |
| HDAC6 | |||||
| Benign | 28 | −0·02 | 0·93 | −0·004 | 0·98 |
| DCIS | 7 | 0·82 | 0·02 | 0·72 | 0·17 |
| IDC | 2 | na | na | na | na |
| Ki-67 | |||||
| Benign | 35 | 0·13 | 0·45 | 0·14 | 0·45 |
| DCIS | 13 | −0·29 | 0·34 | −0·74 | 0·009 |
| IDC | 8 | −0·43 | 0·29 | −0·86 | 0·03 |
| p21 | |||||
| Benign | 37 | −0·18 | 0·28 | −0·19 | 0·27 |
| DCIS | 13 | −0·51 | 0·07 | −0·58 | 0·06 |
| IDC | 9 | 0·31 | 0·42 | 0·35 | 0·44 |
PBMC, peripheral blood mononuclear cells; HDAC, histone deacetylase; ac, acetylation; DCIS, ductal carcinoma in situ; IDC, invasive ductal carcinoma; na, not available.
Significant results are presented in bold font.
*
Partial correlation P value is adjusted for age and use of non-steroidal anti-inflammatory drugs.