Skip to main content
. 2023 Jan 7;108(7):1740–1746. doi: 10.1210/clinem/dgac759

Table 2.

The top 15 most influential variables predicting metformin failure in the complete feature set ranked by variable importance in the combined population

Variable Mean absolute SHAP value Direction
Baseline hemoglobin A1c 0.762 Positive
Other screening for suspected conditions (CCS 258) 0.055 Inverse
Diabetes with complications (CCS 50) 0.044 Positive
Body mass index 0.041 U-shape
Potassium 0.041 Positive
Medical examination/evaluation (CCS 256) 0.030 Inverse
Sodium 0.027 Inverse
Albumin 0.025 Inverse
Triglycerides 0.022 Positive
Heart Rate 0.021 Positive
Low-density lipoprotein 0.020 U-shape
Mean cell hemoglobin 0.020 Positive
Creatinine 0.020 U-shape
High-density lipoprotein 0.018 Inverse
Age 0.016 Positive

Abbreviation: CCS, Clinical Classifications Software; SHAP, SHapley Additive exPlanations.