Table 2.
Statistical comparisons (P values) of five VDR SNP between the obese (n 99) and normal-weight (n 82) adult males, Shenzhen City, Guangdong Province, China, analysed with different genetic models
| Genetic model* | SNP† | <35 years | 35–<50 years | ≥50 years | Cochran’s and Mantel–Haenszel |
|---|---|---|---|---|---|
| Genotypic frequency | TaqI | 0·788 | 0·562 | 0·360 | 0·366 |
| ApaI | 0·330 | 0·090 | 0·786 | 0·123 | |
| rs3782905 | 0·326 | 0·101 | 0·492 | 0·043 | |
| FokI | 0·574 | 0·592 | 0·299 | 0·596 | |
| Cdx-2 | 0·400 | 0·353 | 0·758 | 0·408 | |
| Allelic frequency | TaqI | 0·792 | 0·570 | 0·375 | 0·374 |
| ApaI | 0·303 | 0·343 | 0·852 | 0·215 | |
| rs3782905 | 0·142 | 0·744 | 0·225 | 0·473 | |
| FokI | 0·399 | 0·750 | 0·677 | 0·914 | |
| Cdx-2 | 0·175 | 0·127 | 0·952 | 0·051 | |
| Dominant model | TaqI | 0·788 | 0·562 | 0·360 | 0·366 |
| ApaI | 0·664 | 0·088 | 0·786 | 0·144 | |
| rs3782905 | 0·141 | 0·306 | 0·234 | 0·203 | |
| FokI | 0·292 | 0·417 | 0·234 | 0·780 | |
| Cdx-2 | 0·183 | 0·334 | 0·786 | 0·157 | |
| Recessive model | TaqI | –‡ | –‡ | –‡ | –‡ |
| ApaI | 0·137 | 0·440 | –‡ | 0·782 | |
| rs3782905 | 0·561 | 0·151 | 0·664 | 0·259 | |
| FokI | 0·817 | 0·778 | 0·660 | 0·626 | |
| Cdx-2 | 0·460 | 0·163 | 0·530 | 0·099 |
VDR, vitamin D receptor gene.
*
The dominant model is used for major homozygotes v. combination of minor homo- and heterozygotes. The recessive model is used for combination of major homo- and heterozygotes v. minor homozygotes.
†
RefSNP ID numbers are: rs731236 for TaqI, rs7975232 for ApaI, rs2228570 for FokI and rs11568820 for Cdx-2.
‡
The P value was not available due to at least one sum of rows or columns being zero.