Table 3.
Multiple regression analyses to scrutinise independent associations of 25(OH)D3 and iPTH with fasting serum lipids* among well-functioning German elderly aged 66–96 years (n 193), Giessen, Germany, July–October 2008 (GISELA study)
| Dependent variables | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| log TAG (mg/dl) | TC (mg/dl) | log HDL-C (mg/dl) | LDL-C (mg/dl) | LDL-C:HDL-C | TC:HDL-C | |||||||
| β | P | β | P | β | P | β | P | β | P | β | P | |
| Entire cohort (n 193)† | ||||||||||||
| 25(OH)D3 (nmol/l) | −0·071 | 0·338 | −0·050 | 0·482 | 0·153 | 0·032 | −0·087 | 0·238 | −0·200 | 0·009 | −0·193 | 0·010 |
| iPTH (pmol/l) | −0·048 | 0·503 | −0·125 | 0·080 | −0·070 | 0·301 | −0·014 | 0·863 | −0·037 | 0·621 | −0·018 | 0·813 |
| R 2 entire cohort | 0·211 | 0·052 | 0·025 | |||||||||
| Women (n 138)‡ | ||||||||||||
| 25(OH)D3 (nmol/l) | −0·180 | 0·040 | −0·080 | 0·380 | 0·197 | 0·027 | −0·152 | 0·094 | −0·298 | <0·001 | −0·302 | <0·001 |
| iPTH (pmol/l) | −0·071 | 0·390 | −0·088 | 0·332 | 0·034 | 0·690 | −0·072 | 0·422 | −0·070 | 0·423 | −0·069 | 0·430 |
| R 2 women | 0·184 | 0·149 | 0·067 | 0·069 | ||||||||
| Men (n 55)‡ | ||||||||||||
| 25(OH)D3 (nmol/l) | 0·046 | 0·747 | −0·061 | 0·660 | −0·012 | 0·930 | −0·064 | 0·639 | −0·071 | 0·615 | 0·109 | 0·455 |
| iPTH (pmol/l) | −0·015 | 0·916 | −0·252 | 0·063 | −0·297 | 0·033 | −0·175 | 0·189 | 0·030 | 0·826 | 0·064 | 0·643 |
| R 2 men | 0·051 | |||||||||||
25(OH)D3, 25-hydroxycholecalciferol (25-hydroxyvitamin D3); iPTH, intact parathyroid hormone; TC, total cholesterol; HDL-C, HDL cholesterol; LDL-C, LDL cholesterol; %TBF, percentage of total body fat; PAL, physical activity level.
Multiple linear regression analyses were performed using stepwise procedure and the respective serum lipid as dependent variable. Serum 25(OH)D3 and iPTH concentrations were simultaneously included as fixed independent variables in each of the models. The results of the analyses are expressed in terms of the standardised coefficient beta (β) and the adjusted coefficient of determination (R 2) for the final model provided that the association of 25(OH)D3 or iPTH with serum lipids reached statistical significance.
Adjusted for sex, sex interaction (sex×25(OH)D3 and sex×iPTH), age, %TBF, PAL, alcohol consumption, smoking behaviour and the use of lipid-modifying drugs. Effect modification by sex was significant for log HDL-C (sex×25(OH)D3; P<0·0001), LDL-C (sex×iPTH; P=0·017) and LDL-C:HDL-C (sex×25(OH)D3; P=0·006).
Adjusted for age, %TBF, PAL, alcohol consumption, smoking behaviour and the use of lipid-modifying drugs.